Chlorobutanol Hemihydrate CAS 6001-64-5 is an efficient antibacterial & antifungal preservative, widely used as pharmaceutical excipient for ophthalmic, injection, nasal & cosmetic formulations. It has camphor-like odor, easy sublimation, available in anhydrous and hemihydrate grades, complying with BP/EP/USP/JP pharmacopoeia standards. TNJ Chemcial is the key manufacturer and exporter since from 2001. We guarantee high quality, competitive price, stable supply, fast delivery and tech support etc. To find more, please contact sales@tnjchem.com
Product Information
Chemical Name: 1,1,1-Trichloro-2-methyl-2-propanol
Synonyms: Chlorbutol, Chloretone
CAS No.: 57-15-8 (Anhydrous) / 6001-64-5 (Hemihydrate)
EINECS: 200-317-6
Molecular Formula: C₄H₇Cl₃O (anhydrous); C₄H₇Cl₃O·0.5H₂O (hemihydrate)
Molecular Weight: 177.46 (anhydrous); 186.46 (hemihydrate)
Grade: Pharma grade, BP / EP / USP / JP
Chemphysical Properties
Appearance: White or colourless crystalline solid
Odor: Characteristic camphor-like odour
Melting point: 95–99°C (anhydrous); 77–79°C (hemihydrate)
Boiling point: 167 °C
Solubility: Slightly soluble in cold water, freely soluble in ethanol, ether, chloroform, glycerin, acetone & fixed oilsFeature: Volatile, easy to sublime
Quality Specification
| Item | Specification |
|---|---|
| Assay | 98.0%–100.5% |
| Loss on drying | ≤0.6% (anhydrous); 4.5%–5.5% (hemihydrate) |
| Melting range | 95–99°C (anhydrous) /77–79°C (hemihydrate) |
| Acidity / Alkalinity | Complies |
| Chloride | ≤0.05% |
| Heavy metals (Pb) | ≤10 ppm |
| Residue on ignition | ≤0.1% |
Use & Application
Pharmaceutical excipient (main use): Antimicrobial preservative for eye drops, injections, nasal preparations, ear drops, dental & topical ointments, typical dosage 0.5% w/v.
Cosmetic preservative for cream, lotion and non-aqueous personal care formulas.
Plasticizer for cellulose ester & cellulose ether.
Mild local analgesic & sedative for dental & veterinary application.
Packing
25kg drum (cardboard drum with PE inner bag), or 5kg / 1kg aluminium bottle for lab & pharma small batch.
Delivery & Storage
Storage: Keep tightly closed, cool & dry place, away from heat and direct sunlight.
Transport: Classified as ordinary chemical, avoid strong oxidizer. Easy sublimation, seal strictly.
Shelf life: 24 months under proper storage.
* All chemicals purchased shall be used for legal purpose only and must not be diverted for nacrotics, weapons or other illegal use.
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